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In Silico Comparative Analysis of the Functional, Structural, and Evolutionary Properties of SARS-CoV-2 Variant Spike Proteins

In Silico Comparative Analysis of the Functional, Structural, and Evolutionary Properties of SARS-CoV-2 Variant Spike Proteins

The protein sequences of wild-type SARS-Co V-2 and its 6 variants—D614 G, alpha (B.1.1.7), beta (B.1.351), delta (B.1.617.2), gamma (P.1), and omicron (B.1.1.529)—were obtained from the NCBI database. The list of all the variants with the NCBI accession numbers are mentioned in Table 1. Multiple sequence alignment of all the protein was done using Clustal X2 software [8] to identify and confirm common and specific mutations among all the sequences listed in Table 1.

Renukaradhya K Math, Nayana Mudennavar, Palaksha Kanive Javaregowda, Ambuja Savanur

JMIR Bioinform Biotech 2022;3(1):e37391