Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study

Younga Heather Lee   ^{1, 2, 3 *} , PhD ;   Yingzhe Zhang   ^{1, 2, 4 *} , MS ;   Chris J Kennedy   ^{3, 5} , MPA, PhD ;   Travis T Mallard   ^{1, 2, 3} , PhD ;   Zhaowen Liu   ^{1, 2, 3, 6} , PhD ;   Phuong Linh Vu   ⁷ ;   Yen-Chen Anne Feng   ^{1, 2, 3, 8} , MS, ScD ;   Tian Ge   ^{1, 2, 3, 5} , PhD ;   Maria V Petukhova   ⁹ , PhD ;   Ronald C Kessler   ⁹ , PhD ;   Matthew K Nock   ^{10, 11, 12} , PhD ;   Jordan W Smoller   ^{1, 2, 3, 5} , MD, ScD

¹ Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States

² Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States

³ Department of Psychiatry, Harvard Medical School, Boston, MA, United States

⁴ Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States

⁵ Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, United States

⁶ School of Computer Science, Northwestern Polytechnical University, Xi’an, China

⁷ Harvard College, Harvard University, Cambridge, MA, United States

⁸ Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan

⁹ Department of Health Care Policy, Harvard Medical School, Boston, MA, United States

¹⁰ Department of Psychology, Harvard University, Cambridge, MA, United States

¹¹ Mental Health Research Program, Franciscan Children’s, Brighton, MA, United States

¹² Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States

*these authors contributed equally