Drug discovery and development

IL-6/GP130/JAK/STAT3 Pathway Activation in Pancreatic Ductal Adenocarcinoma and Its Association With Clinical Features: Protocol for a Retrospective Cross-Sectional Study

Claudia Mellenthin, Fabien Schaller, Lucie Vignot, Sarah Peisl, Rita Vesce, Irene Esposito, Carmen Gonelle-Gispert, Cornelia Schneider, Michel Adamina, Leo Hans Bühler

JMIR Res Protoc 2025 (Dec 15); 14:e76811

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Machine Learning–Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation

Samuel Kakraba, Srinivas Ayyadevara, Aayire Yadem Clement, Kuukua Egyinba Abraham, Cesar M Compadre, Robert J Shmookler Reis

JMIR AI 2025 (Dec 03); 4:e77890

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Protein-Protein Interactions in Papillary and Nonpapillary Urothelial Carcinoma Architectures: Comparative Study

Charissa Chou, Yiğit Baykara, Sean Hacking, Ali Amin, Liang Cheng, Alper Uzun, Ece Dilber Gamsiz Uzun

JMIR Bioinform Biotech 2025 (Nov 27); 6:e76736

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Heterogeneous Network With Multiview Path Aggregation: Drug–Target Interaction Prediction Study Design

Haixue Zhao, Kui Yao, Yunjiong Liu, Chao Che, Lin Tang

JMIR Med Inform 2025 (Oct 02); 13:e74974

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Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem

Sakshi Sardar, Cheryl D Coon, Scottie Kern, Huong Huynh, Diane Stephenson, Joshua Rubin Abrams, Grace V Lee, Cecile Ollivier, Joseph A Hedrick, Martijn LTM Müller, Luc J W Evers, Lada Leyens, Collin Hovinga, Shu Chin Ma, Klaus Romero

J Med Internet Res 2025 (Jul 31); 27:e67052

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Harnessing AI and Quantum Computing for Revolutionizing Drug Discovery and Approval Processes: Case Example for Collagen Toxicity

David Melvin Braga, Bharat Rawal

JMIR Bioinform Biotech 2025 (Jul 22); 6:e69800

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Discovery of Novel Inhibitors of HMG-CoA Reductase Using Bioactive Compounds Isolated From Cochlospermum Species Through Computational Methods: Virtual Screening and Algorithm Validation Study

Toba Isaac Olatoye

JMIRx Bio 2025 (Jul 10); 3:e71675

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Identification of Compounds With Potential Dual Inhibitory Activity Against Drug Efflux Pumps in Resistant Cancer Cells and Bacteria: Protocol for a Systematic Review

Elina Beleva, Antonia Diukendjieva, Ilza Pajeva, Ivanka Tsakovska

JMIR Res Protoc 2025 (Jun 05); 14:e66197

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Effects of a Monophasic Hormonal Contraceptive With Norgestimate+Ethinyl Estradiol on Menstrual Bleeding: Protocol and Design of a Multicenter, Prospective, Open-Label, Noncomparative Study in Italy

Angelo Cagnacci, Giovanni Grandi, Giampiero Capobianco, Anna Maria Fulghesu, Giuseppe Morgante, Vincenzo Biondelli, Elena Piccolo, Elena Casolati, Mario Mangrella

JMIR Res Protoc 2025 (Mar 31); 14:e63683

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